“通过高压卧式珠(球)磨机生产的药物纳米晶体。高压卧式珠(球)磨机已经应用在生产乳液和悬浮液的各个领域中多年,并且目前用于食品工业,例如牛奶的均质化。该技术的一个明显优势是易于扩展,甚至可以扩展到非常大的容量。在制药工业中,通过该技术生产肠胃外乳液。”
图:采用再循环方法的珠(球)磨机Dispermat SL示意图
“Drug Nanocrystals produced by High- Pressure Homogenization. High-pressure homogenization has been applied for many years in various areas for the production of emulsions and suspensions and is currently used in food industry like homogenization of milk. A distinct advantage of this technology is its ease for scaling up, even to very large volumes. In the pharmaceutical industry parenteral emulsions are produced by this technology.”